Subject
Systematic reviews, meta-analyses, scoping reviews, and synthesis methods.
A meta-analysis of 12 randomized trial publications found higher reported response rates and lower tinnitus and anxiety scores in acupuncture-based treatment groups, while biomarker results were inconclusive.
Frontiers in neurology5 min read
A meta-analysis found that circulating BDNF did not reliably distinguish children with cerebral palsy, non-syndromic intellectual disability or Down syndrome from controls, or track severity within affected groups.
Frontiers in neurology4 min read
Across 10,208 participants, adding Compound Danshen Dripping Pills to conventional therapy was associated with better reported angina and ECG responses than conventional therapy alone or nitrate-containing therapy, but substantial heterogeneity and moderate-to-very-low certainty prevented definitive conclusions.
Frontiers in pharmacology6 min read
Across 46,572 patients receiving immune checkpoint inhibitors, higher pretreatment BMI was associated with more favorable average survival measures, with substantial uncertainty between studies.
Frontiers in immunology5 min read
Across randomized trials in youth with overweight or obesity, high-intensity interval training showed no statistically significant advantage over continuous aerobic exercise for body weight, BMI or body fat percentage.
Frontiers in pediatrics4 min read
A systematic review found moderate-certainty evidence of a better SRI-4 response at 48 to 52 weeks with telitacicept in placebo-controlled randomized trials, while evidence from other designs was much less certain.
Frontiers in medicine5 min read
A systematic review of 21 studies found a small positive association between literary or prosocial reading and empathy-related outcomes. The pattern was uneven, with engagement and reader characteristics appearing to shape affective and prosocial responses.
Frontiers in psychology4 min read
A protocol sets out a scoping review of financial incentives for nurses in low- and middle-income countries, focusing on scheme design, motivation and individual performance.
Public health challenges3 min read
A systematic review of stand-alone psychoeducation for children and adolescents exposed to potentially traumatic experiences found mixed results for trauma-related knowledge. Two studies reported higher scores in intervention groups, while a third found no difference after 10 months.
European journal of psychotraumatology3 min read
The analysis found positive bile cultures in 77.3% of 5,147 sampled people, with Gram-negative organisms making up most isolates. But the studies varied sharply, and resistance data could not be combined into a reliable overall estimate.
Annals of Saudi medicine4 min read
A systematic review found no clear excess of side effects when intrathecal immune checkpoint inhibitors were added to systemic treatment for leptomeningeal disease, while survival differences remained uncertain.
Neurosurgical review5 min read
Researchers found a scattered set of genetic candidates, while warning that the evidence is too limited to identify a definitive cause.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery3 min read
Researchers say inflammation linked to cerebral palsy can persist beyond the perinatal period, with higher levels associated with greater severity in the studies reviewed.
Pediatric research4 min read
A meta-analysis of seven studies found altered timing and occupancy of resting brain states in ASD, alongside promising but highly variable classification performance.
Journal of autism and developmental disorders4 min read
A review of treatments for symptomatic vaginal laxity supports pelvic floor muscle training as first-line, while finding low-certainty evidence for radiofrequency devices and very low-certainty evidence from surgical cohorts.
International urogynecology journal3 min read
The review found myelitis and optic neuritis were the leading reported presentations, while corticosteroids and treatment discontinuation were common and favorable outcomes were reported in 71.7% of cases. Because the evidence came from published case reports and case series, it does not estimate incidence or compare treatments.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology3 min read
A systematic review of six randomized trials involving 105 participants found that most studies reported gains in comprehension, word processing and language performance, but differences between trials limited direct comparisons.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology4 min read
A review of 18 studies found low energy availability common among university athletes and often accompanied by disordered-eating indicators. Evidence for anxiety and depression was thinner, and the mostly cross-sectional research could not establish cause or direction.
Journal of sports sciences4 min read
The evidence points to several ways complement regulators may help glioma cells avoid immune attack and support proliferation, invasion or treatment resistance, while leaving clinical benefit unproven.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico4 min read
A reanalysis of public chickpea RNA-seq datasets found that HDBSCAN produced a more stress-specific drought signal than conventional tests and HN-score meta-analysis, but its performance depended on data richness.
Genes & genomics4 min read
A systematic review found that vascular graft and endograft infections after abdominal aortic aneurysm repair were uncommon but relevant complications. Its pooled incidence estimate was lower after EVAR than open surgery, but wide variation in diagnostic criteria and limited microbiological data for OS make the comparison harder to interpret.
Infection3 min read
A review of 3,479 kidney transplant recipients found possible advantages and a potential drawback associated with double-J stents compared with single-J stents.
Clinical transplantation and research5 min read
A methods paper presents NMADTA, an R package for combining uneven diagnostic-test evidence while making the assumptions behind missing data explicit.
Research Synthesis Methods3 min read
A benchmark of three large language models found a clear gap between basic study information and statistical results, with missing fields making up most analyzed errors.
Research Synthesis Methods3 min read
A methods analysis found that exact within-study variance calculations and BGLMM generally performed better than a standard approximate logit approach when diagnostic-test studies were sparse or small.
Research Synthesis Methods3 min read
A peer-reviewed systematic review found sparse reporting of treatment switching and no formal adjustment for it in the oncology meta-analyses examined.
Research Synthesis Methods4 min read