Subject
Diagnosis, treatment, trials, surgery, and patient outcomes.
A European expert project has produced practical guidance for adult-onset IgA vasculitis, but the review found major gaps in evidence for treatment and long-term kidney care.
Nature reviews. Rheumatology4 min read
Adults assessed after ACL reconstruction had poorer operated-limb proprioception and dynamic balance than healthy controls, while muscle-activity differences did not remain significant after correction.
Knee surgery & related research5 min read
An analysis of 96 fatal pediatric traumatic brain injury cases found that traffic accidents involved mainly adolescents, while abusive head trauma was concentrated in children aged two or younger.
International journal of legal medicine5 min read
In 65 adults using the MiniMed 780G system, mean infusion-set wear rose to 6.1 days after the switch, while only 48.3% maintained the full seven-day duration at six months.
Endocrine4 min read
An analysis of public tissue gene-expression data found overlapping aging-related signals in periodontitis and rheumatoid arthritis, alongside similar immune-cell patterns.
Acta odontologica Scandinavica4 min read
A survey of healthcare professionals highlights organizational and patient-facing barriers to delivering prehabilitation for people with pancreatic cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer3 min read
A study of children under 3 found RSV in 39.8% of nasal swabs overall, with positivity varying across primary care and emergency care.
BMJ open respiratory research4 min read
Patients carefully chose family caregivers for a web-based support programme, linking the decision to caregiver burden and hopes for difficult conversations.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer4 min read
In cultured macrophages, high oxygen and LPS were associated with lower SIRT1 and higher TLR4/NF-κB activity and inflammatory cytokines.
Pediatric research3 min read
Orange-peel-mediated zinc oxide nanoparticles showed activity against selected microbial isolates and cancer cell lines in laboratory assays. The findings do not establish treatment efficacy or safety in people.
Scientific reports5 min read
An automated fluorescence video system detected D. immitis microfilariae more often than a manual wet mount in diluted blood, but the evidence came from one infected donor and one uninfected animal.
Parasites & vectors4 min read
In 1,198 non-shockable out-of-hospital cardiac arrests, 13.9% had any documented return of spontaneous circulation and 12.2% maintained it through EMS care. Witnessed arrests and PEA were associated with higher odds in adjusted models, while the study could not establish cause and effect.
International journal of emergency medicine4 min read
A multidisciplinary expert consensus recommends finerenone for selected older adults with chronic kidney disease and albuminuria, while urging individualized monitoring and caution about gaps in evidence.
Aging medicine (Milton (N.S.W))5 min read
Compound 2 reacted less with an 8mer DNA model than Compound 1, DDP and OxPt, but limited mass-spectrometry evidence could not establish where it attached or whether the pattern would hold in living systems.
Bioinorganic chemistry and applications4 min read
In 66 recordings from 22 children, scalp high-frequency oscillations were more common in hypsarrhythmia groups and occurred at higher rates than in IED groups. The authors say the measures may complement EEG assessment, but are not ready to stand alone.
Experimental physiology5 min read
Researchers found several ovarian changes in female rats given environmentally relevant naproxen exposure, alone or in a chemical mixture. The results raise a reproductive-risk question without establishing human effects.
Clinical and experimental reproductive medicine4 min read
A study found higher TRIM59 expression in bladder cancer tissues and cell lines, with links to advanced clinical features and shorter survival. Experiments connected TRIM59 to PTRF protein turnover and cancer-cell growth and invasion, but did not test treatment response.
Cancer science4 min read
A narrative review maps standard care and newer therapies for discoid lupus erythematosus, finding the clearest reported skin signals with anifrolumab and enpatoran while highlighting gaps in DLE-specific and long-term evidence.
Dermatology and therapy4 min read
A mouse study with human colorectal cancer data points to a macrophage PABPC4-SPP1 pathway linked to tumor growth and immune suppression, but it does not test a treatment in patients.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)4 min read
A preclinical rat study found that a bacteria-loaded hydrogel improved implantation and tissue repair while shifting immune and uterine microbial markers toward sham-operated animals.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)4 min read
European clinicians surveyed about ADHD care pointed to gaps in treatment personalisation, the use of evidence in practice and access to guidance.
European child & adolescent psychiatry3 min read
A laboratory study found that hip-specific DXA and newer measures of bone quality were strongly associated with the force needed to pull screws from cadaveric femurs.
Archives of osteoporosis4 min read
Alpha-synuclein showed properties consistent with small, micelle-like assemblies in low-salt laboratory conditions, while higher salt was linked to larger clusters, condensates and some fibrils over time.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)4 min read
Fatty pancreas was present in 8 of 22 patients with pancreatic neoplastic cystic lesions, but the study found no statistically significant overall difference from matched controls.
Digestive diseases and sciences4 min read
The findings point to endosomal acidity, the pH inside cell compartments called endosomes, as a possible way to influence harmful microglial activity after stroke. The evidence remains preclinical and does not establish a treatment for people.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)5 min read
A Seoul analysis of daily health-service counts for people under 19 found that ambient VOC mixtures were associated with higher outpatient visits and hospital admissions for atopic dermatitis and asthma. Toluene carried the highest mixture weight for both outcomes, while scenario-based burden estimates depended on a hypothetical lower-exposure benchmark.
Journal of exposure science & environmental epidemiology3 min read
Among people with hypertension, esaxerenone was associated with fewer cardiovascular events than spironolactone, with the gap concentrated in heart failure and atrial fibrillation.
Journal of human hypertension4 min read
A retrospective study of 611 patients reports a mean AUC of 0.975 and higher attention scores in physician-annotated regions, while clinical benefit remains untested.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery4 min read
In a retrospective study, ultrasound measures were associated with previous enlargement among small ACR TI-RADS 5 thyroid nodules, while the predictive model still needs prospective testing.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery4 min read
The report describes outcomes after transoral CO₂ laser modified posterior cordotomy in women with post-thyroidectomy bilateral vocal fold paralysis, but it cannot establish causation.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery3 min read
In 56 patients with F2–F3 esophagogastric varices, rebleeding was more common and variceal remission less frequent in groups with more severe EUS-defined vascular abnormalities. The retrospective findings suggest a possible risk-stratification tool, but they do not show that using it to choose treatment improves outcomes.
Surgical endoscopy3 min read
Among 2,604 cancer survivors transitioned to primary care, 440 later had an oncology visit, and recurrence or new disease was detected in 4.8% of the full cohort.
Journal of cancer survivorship : research and practice3 min read
Among 106 peer surgeons, 50 adopted robotics, while high-volume index adopters were associated with lower peer adoption across seven analytical approaches.
Obesity surgery4 min read
In a 24-patient retrospective cohort, clear aligners were associated with less incisor tipping and vertical intrusion than fixed appliances in a specific jaw-surgery treatment setting.
Aesthetic plastic surgery4 min read
A cohort analysis of 6,793 Chinese adults found associations between reported cognitive problems, frailty progression and subsequent all-cause mortality, with larger estimates when self- and interviewer-reported problems were combined.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology4 min read
Researchers reported distinct craniofacial skeletal and masticatory-muscle patterns between patients with dislocation/subluxation and internal derangement, along with several muscle-bone correlations.
Oral and maxillofacial surgery4 min read
A trial of 36 healthy patients found lower self-reported pain with a 20% benzocaine patch than gel for cheek-side and palate-side injections, but observer-rated buccal pain did not differ significantly.
Oral and maxillofacial surgery4 min read
A study of 395 adults treated for distal femur fractures found similar rates of later same-side hip fracture whether surgeons added a prophylactic femoral neck screw or not. Only six fractures occurred, and differences between the groups mean the findings cannot settle whether the added fixation is protective.
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie3 min read
In a 40-hip comparison after pelvic radiotherapy, trabecular metal cups were linked with higher revision-free survivorship than reconstruction cages, although the authors describe the findings as hypothesis-generating.
International orthopaedics4 min read
In two matched groups of 862 patients, testosterone replacement therapy exposure before surgery was associated with higher reported five-year odds of pseudoarthrosis, adjacent segment disease and cervical reoperation.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society4 min read