Subject
Diagnosis, treatment, trials, surgery, and patient outcomes.
Zinc oxide nanoparticles made with olive-leaf extract were most active against HepG-2 liver cancer cells in cell tests, while their effects on normal cells underscored the need for further safety work.
RSC advances4 min read
In a randomized trial at a tertiary hospital in central India, women who received two warm compressions at the lower back had lower pain scores at later checks than those given routine care.
Cureus3 min read
A small study found that Azure Kinect tracked some shoulder and elbow movements well, but overestimated postoperative shoulder flexion and external rotation compared with an IMU reference.
Frontiers in bioengineering and biotechnology4 min read
Among 2,001 high-thrombotic-risk STEMI patients treated with PCI, those who received post-PCI PACT had similar observed outcomes to those who did not, but the observational study could not establish equivalence.
Frontiers in pharmacology4 min read
Research on biologic therapy for Crohn’s disease grew steadily over the decade, while newer work increasingly centered on biomarkers, prediction and treatment comparisons.
Frontiers in pharmacology3 min read
A randomized trial in 296 adults with septic shock reported lower 28-day mortality after anisodamine was added to standard therapy, but it did not establish that changes in lactate caused the difference.
Frontiers in pharmacology3 min read
A study combining ovarian tumor data, survival modeling and cell experiments found that SPP1-related patterns tracked with poorer outcomes and changed after PI3 silencing in laboratory models.
Frontiers in immunology4 min read
People whose health vulnerability rose between two assessments had the highest observed cardiovascular disease risk in a 16,072-person UK Biobank analysis. Over a median 8.9 years, 3,033 first cardiovascular events were recorded.
Frontiers in public health5 min read
A study of clinical malaria isolates and humanized mice found that P. malariae was associated with young red blood cells and could be detected in immature bone-marrow cells. The result broadens the picture of where the parasite may persist, but the marrow evidence came from mice, not human patients.
Emerging microbes & infections4 min read
A Chinese cohort analysis found that higher baseline intrinsic-capacity deficit scores were associated with less favorable BADL and IADL trajectories over 10 years. The BADL rate effect was small, while the primary IADL rate estimate was not statistically significant and changed under missing-data assumptions.
Frontiers in public health4 min read
Researchers found that LINC00887 tracked with higher glycolysis, M2 macrophage polarization and weaker CD8+ T-cell activity in clear cell kidney cancer models. Lowering the RNA slowed tumors in mice, while reducing UPF1 reversed the pattern.
Frontiers in immunology4 min read
A qualitative study identified barriers to perinatal mental-health support and six participant-proposed priorities for making services easier to find, reach and use.
Frontiers in global women's health3 min read
All four adults stayed on treatment, but the retrospective report included selected responders and cannot establish a causal treatment effect.
Frontiers in pharmacology4 min read
Children who underwent neonatal repair for aortic arch obstruction showed lower motor performance at later assessments, while cognitive scores were broadly comparable with normative expectations.
Frontiers in pediatrics5 min read
A prospective, open-label study reported that two people with chronic stroke-related upper-limb impairment completed long-term myoelectric virtual-reality training, while changes in motor function remained preliminary.
Frontiers in rehabilitation sciences4 min read
A same-site study found that a prespecified transcript score reproduced discrimination between Kawasaki disease and febrile controls, while CHROMR showed the clearest association among candidate RNAs. The findings do not establish mechanism, causality or added diagnostic value beyond the existing score.
Frontiers in immunology5 min read
A small, single-group study found that MINDSET 2.0 met its prespecified feasibility criteria, while leaving unanswered whether the tool improves health or connects people with recommended support.
Frontiers in neurology3 min read
In one tertiary dermatology clinic in Fujian, China, house dust mite was the most common reported trigger among 47 children and adolescents with atopic dermatitis, while recorded severity differed between two source batches.
Frontiers in pediatrics5 min read
A prospective cohort found that higher remnant cholesterol was associated with newly diagnosed diabetic retinopathy, but it did not show that lowering cholesterol would prevent the condition.
Annals of medicine4 min read
In 384 matched patients, a history of periodontitis was associated with higher odds of peri-implantitis, while case-only cultures showed a mixed range of organisms.
Frontiers in cellular and infection microbiology4 min read
A Sofia pilot found that over-the-counter respiratory product sales were practical to collect and generally higher in January, but it did not show that pharmacy data can predict infections.
Frontiers in public health4 min read
A cross-sectional study of 442 women in Borama, Somaliland, found a substantial burden of self-reported postpartum depressive symptoms and incomplete continuity of maternal care. The results point to gaps in follow-up and disclosure, but the study cannot show cause or estimate rates across the whole district.
Global health action4 min read
The review covered 1,764 participants with autoimmune primary adrenal insufficiency. Comparative studies consistently reported poorer quality of life, but treatment findings were mixed.
Frontiers in endocrinology3 min read
A laboratory cell study found that proteins linked to Alzheimer’s disease were not engaged uniformly by macroautophagy. Phosphorylated tau showed the largest reported abundance change and a high LC3-associated fraction, while amyloid-beta showed limited engagement.
Frontiers in neuroscience4 min read
Nearly half of the breast cancer randomized trials examined had at least one research-waste feature, while early discontinuation was associated with higher odds of waste.
Frontiers in oncology4 min read
A model combining three preoperative MRI and clinical features showed similar performance in training and validation groups for predicting recurrence after breast cancer surgery, but the retrospective study does not establish that it will work elsewhere or improve care.
Frontiers in oncology5 min read
The study combined serum metabolomics with public gene-expression data to examine two traditional Chinese medicine classifications in rheumatoid arthritis.
Frontiers in immunology4 min read
A survey of US adults already taking rimegepant found sex-related differences in reported reasons and triggers for short-term prevention, but it did not test efficacy.
Frontiers in neurology4 min read
In 140 clinical isolates from one Lebanese medical center, NDM was the most common carbapenemase and several newer agents showed sharply different laboratory activity by resistance type.
Frontiers in cellular and infection microbiology4 min read
A mouse experiment found that induced hypertension did not significantly intensify alpha-synuclein-linked dopaminergic neuron loss, glial responses or most inflammatory signals.
Frontiers in immunology3 min read
A 36-patient cohort reported frequent remission and improved protein loss after rituximab plus low-dose glucocorticoids, but the study cannot show whether the steroids added benefit.
Frontiers in pharmacology4 min read
A survey of 105 pharmacists aged 45 or younger found strong interest in onco-cardiology but limited reported clinical experience, weaker hospital-community pharmacy collaboration and a strong demand for online education.
Circulation reports3 min read
A qualitative review found Grade A recommendations for several cognitive, exercise, memory and stimulation approaches, while the evidence was too varied for pooled treatment effects.
Frontiers in neurology4 min read
Among U.S. adults aged 65 and older, the age-adjusted breast cancer mortality rate fell from 71.58 per 100,000 in 1999 to 50.83 in 2020, even as annual deaths rose from 24,760 to 27,409. Mortality was highest among Black women and varied widely between jurisdictions.
Frontiers in oncology4 min read
The evidence did not demonstrate that oral melatonin reduced multiple sclerosis activity, disability progression or new MRI activity, and possible symptom benefits remain uncertain.
Frontiers in neurology3 min read
Children assigned to a bundled ERAS pathway had a shorter observed hospital stay, earlier gastrointestinal recovery and fewer in-hospital complications. The study did not assess hernia recurrence after discharge.
Frontiers in surgery4 min read
A South African public-sector model found PCV20 offered more modeled health benefit than PPSV23, but only HIV-targeted vaccination met the primary cost-effectiveness benchmark.
Human vaccines & immunotherapeutics4 min read
A retrospective single-center study found that adding baseline LDH, a systemic inflammation score and early radiation esophagitis to clinical and treatment factors improved prediction of grade 2 or higher radiation pneumonitis.
Frontiers in immunology4 min read
In 52 patients with triple-negative breast cancer, tumors linked to poor metastatic outcomes showed changes in gene programs, metabolites, immune-cell makeup and cell spacing, but the small retrospective study cannot establish cause.
Cancer science5 min read
Patients who later underwent total knee replacement had similar one-year spine outcomes to those who did not, although the study was small, retrospective and limited to one center.
Global Spine Journal4 min read