Specialty
A randomized trial in 296 adults with septic shock reported lower 28-day mortality after anisodamine was added to standard therapy, but it did not establish that changes in lactate caused the difference.
Frontiers in pharmacology3 min read
In 384 matched patients, a history of periodontitis was associated with higher odds of peri-implantitis, while case-only cultures showed a mixed range of organisms.
Frontiers in cellular and infection microbiology4 min read
In 140 clinical isolates from one Lebanese medical center, NDM was the most common carbapenemase and several newer agents showed sharply different laboratory activity by resistance type.
Frontiers in cellular and infection microbiology4 min read
A South African public-sector model found PCV20 offered more modeled health benefit than PPSV23, but only HIV-targeted vaccination met the primary cost-effectiveness benchmark.
Human vaccines & immunotherapeutics4 min read
A previously healthy boy with severe adenovirus type 7 pneumonia had strongly neutralizing anti–IFN-ω autoantibodies. The antibodies blocked IFN-ω signaling and antiviral effects in cell experiments and remained detectable after recovery. Small screening groups could not show how common the finding is or whether it predicts severe disease.
Journal of human immunity4 min read
The national records showed more treatment starts even as reported cases edged down, while incomplete departmental data made local comparisons uncertain.
Memorias do Instituto Oswaldo Cruz4 min read
An automated fluorescence video system detected D. immitis microfilariae more often than a manual wet mount in diluted blood, but the evidence came from one infected donor and one uninfected animal.
Parasites & vectors4 min read
A review of published evidence says clinicians should consider mycobacterial infection when a prosthetic-joint infection is culture-negative, indolent, or does not respond to conventional antibacterial therapy. It recommends prolonged culture and individualized care combining surgery with species-directed multidrug therapy.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology3 min read
Among 254 hospitalized adults receiving immune-modulating treatment, vaccinated patients had shorter hospital stays and lower observed mortality than unvaccinated patients. The findings show an association, not proof of a causal effect.
Clinical rheumatology3 min read
A study of 52 dengue patients found two plasma microRNAs associated with warning-sign status and reported strong diagnostic performance, while key accuracy measures and prospective validation are still missing.
Infection3 min read
A structured review of 12 clinical studies involving 794 patients reported higher diagnostic yields for metagenomic next-generation sequencing than for culture-based testing in infective endocarditis. The authors describe the pooled estimates as illustrative and call for standardised testing and randomised trials.
Infection3 min read
Researchers detected DNA from Listeria monocytogenes and Salmonella enteritidis in roughly half of pooled egg samples in Assiut, Egypt. Salmonella DNA was more common than Listeria DNA in stool samples from diarrheic patients, but PCR could not show whether the bacteria were alive or whether eggs infected people.
Scientific reports4 min read
In 172,422 adults who underwent posterior lumbar interbody fusion, those with a preoperative epidural injection had slightly more infections and nerve injuries, while dural leaks did not differ significantly.
Global spine journal4 min read