A Qatar hospital study found widespread DNA-methylation differences associated with preterm birth in maternal peripheral blood and neonatal cord blood. Most signals were tissue-specific, with a smaller set shared between mothers and newborns.
Frontiers in epigenetics and epigenomics4 min read
Researchers report that oligozoospermic sperm with high reactive oxygen species showed extensive, mostly reduced DNA methylation differences, although only eight samples were profiled and the study cannot establish cause or clinical benefit.
Higher GPER1 expression was associated with longer overall survival among younger women in a retrospective tumor analysis, while laboratory results pointed to cell-cycle changes that need further testing.
Researchers found coordinated changes in fibrosis markers, SOCS3 methylation and JAK2/STAT3 signaling in rat vocal-fold fibroblasts from injured animals and after TGF-β1 exposure. The 5-aza findings point to a possible pathway, but the laboratory work does not establish cause and effect or human treatment relevance.
World journal of otorhinolaryngology - head and neck surgery3 min read
Researchers combined five new genome assemblies, a published genome, population-level sequence data and ATAC-seq profiles to track genetic and chromatin differences across Heliconius erato. The strongest association appeared at intermediate divergence, while two hybrid-zone tests were not significant.