Subject
Genes, genomes, epigenetics, variation, and inheritance.
A laboratory study links chromosome 16q loss and CYLD depletion to genomic instability, a shift in DNA repair and greater Olaparib sensitivity in cancer models, while tissue and public-data results remain associative.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)5 min read
The assemblies shared a conserved gene layout and showed strong species-level clustering, but the mitochondrial data did not settle wider Carabidae relationships.
Ecology and evolution4 min read
TPT1 showed the strongest single-gene separation between sarcopenia and control samples in two bulk muscle-transcriptomic cohorts, while mouse and cell experiments showed matching protein changes. The findings remain exploratory and do not establish causation, disease specificity, or clinical usefulness.
Frontiers in cell and developmental biology4 min read
Researchers combined a pangenome, chromatin-accessibility data and simulations to examine how mutational, regulatory and structural differences may contribute to reproductive isolation while populations exchange genes. The analysis found candidate regions in both adjacent comparisons, but no consistent chromatin signal in the two hybrid zones.
Science advances5 min read