Specialty
Zinc oxide nanoparticles made with olive-leaf extract were most active against HepG-2 liver cancer cells in cell tests, while their effects on normal cells underscored the need for further safety work.
RSC advances4 min read
A study combining ovarian tumor data, survival modeling and cell experiments found that SPP1-related patterns tracked with poorer outcomes and changed after PI3 silencing in laboratory models.
Frontiers in immunology4 min read
Researchers found that LINC00887 tracked with higher glycolysis, M2 macrophage polarization and weaker CD8+ T-cell activity in clear cell kidney cancer models. Lowering the RNA slowed tumors in mice, while reducing UPF1 reversed the pattern.
Frontiers in immunology4 min read
Nearly half of the breast cancer randomized trials examined had at least one research-waste feature, while early discontinuation was associated with higher odds of waste.
Frontiers in oncology4 min read
A model combining three preoperative MRI and clinical features showed similar performance in training and validation groups for predicting recurrence after breast cancer surgery, but the retrospective study does not establish that it will work elsewhere or improve care.
Frontiers in oncology5 min read
Among U.S. adults aged 65 and older, the age-adjusted breast cancer mortality rate fell from 71.58 per 100,000 in 1999 to 50.83 in 2020, even as annual deaths rose from 24,760 to 27,409. Mortality was highest among Black women and varied widely between jurisdictions.
Frontiers in oncology4 min read
A retrospective single-center study found that adding baseline LDH, a systemic inflammation score and early radiation esophagitis to clinical and treatment factors improved prediction of grade 2 or higher radiation pneumonitis.
Frontiers in immunology4 min read
In 52 patients with triple-negative breast cancer, tumors linked to poor metastatic outcomes showed changes in gene programs, metabolites, immune-cell makeup and cell spacing, but the small retrospective study cannot establish cause.
Cancer science5 min read
Researchers linked higher lactate-related marking of HER2 to trastuzumab resistance and traced the signal to a specific site on the protein, while stressing that the finding remains preclinical.
Advanced Science3 min read
A systematic review of 42 observational studies found that published reports cannot show whether one operation is better than another for Merkel cell carcinoma of the digits, hand or wrist.
Plastic Surgery4 min read
Men with prostate cancer and recorded androgen deprivation therapy had higher five-year vertebral compression fracture rates than matched men without recorded therapy, while augmentation was also more common after a fracture.
Global Spine Journal4 min read
A small proof-of-concept study found that intact paraffin-embedded prostate cores could be imaged in three dimensions before histology, with glandular features broadly matching the later slides.
The journal of pathology. Clinical research4 min read
Researchers found shorter survival in PRAME-positive uveal melanomas tested on whole tumour sections and reported similar risk patterns when PRAME was combined with BAP1 or chromosome 3 status.
The journal of pathology. Clinical research4 min read
A randomized trial found fewer postoperative lung complications with a low-dose nasal dexmedetomidine regimen than with saline in older adults having thoracoscopic lung-cancer surgery, while evidence on severity and pneumonia remained limited.
Frontiers in pharmacology4 min read
A cohort study comparing two PSMA PET tracers found similar SUVmax and SUVmean readings but a higher total tumor volume in the Ga-68 PSMA-11 group.
Frontiers in oncology3 min read
In a retrospective study of surgically treated colorectal cancer, smaller tumors were associated with higher standardized metastasis rates, while the strongest survival difference appeared in a selected male subgroup aged 50 or younger with T4 disease.
Frontiers in oncology5 min read
A review of 223 lung cancer records at a Costa Rican public hospital found that 190 patients had died by 2025, while the study also identified delays in diagnosis and treatment and gaps in biomarker testing and access to targeted therapy or immunotherapy.
Cureus4 min read
A 230-patient analysis of HR+/HER2− breast cancer found a higher pCR rate with subtype-directed treatment and different molecular signals among exceptional responders.
The Journal of clinical investigation4 min read
A multicenter review of medical records found 10 documented malignancies among 157 patients with acromegaly, mostly papillary thyroid carcinoma.
Annals of Saudi medicine3 min read
A survey of healthcare professionals highlights organizational and patient-facing barriers to delivering prehabilitation for people with pancreatic cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer3 min read
Patients carefully chose family caregivers for a web-based support programme, linking the decision to caregiver burden and hopes for difficult conversations.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer4 min read
Orange-peel-mediated zinc oxide nanoparticles showed activity against selected microbial isolates and cancer cell lines in laboratory assays. The findings do not establish treatment efficacy or safety in people.
Scientific reports5 min read
Compound 2 reacted less with an 8mer DNA model than Compound 1, DDP and OxPt, but limited mass-spectrometry evidence could not establish where it attached or whether the pattern would hold in living systems.
Bioinorganic chemistry and applications4 min read
Researchers found several ovarian changes in female rats given environmentally relevant naproxen exposure, alone or in a chemical mixture. The results raise a reproductive-risk question without establishing human effects.
Clinical and experimental reproductive medicine4 min read
A study found higher TRIM59 expression in bladder cancer tissues and cell lines, with links to advanced clinical features and shorter survival. Experiments connected TRIM59 to PTRF protein turnover and cancer-cell growth and invasion, but did not test treatment response.
Cancer science4 min read
A mouse study with human colorectal cancer data points to a macrophage PABPC4-SPP1 pathway linked to tumor growth and immune suppression, but it does not test a treatment in patients.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)4 min read
Among 2,604 cancer survivors transitioned to primary care, 440 later had an oncology visit, and recurrence or new disease was detected in 4.8% of the full cohort.
Journal of cancer survivorship : research and practice3 min read
In a 40-hip comparison after pelvic radiotherapy, trabecular metal cups were linked with higher revision-free survivorship than reconstruction cages, although the authors describe the findings as hypothesis-generating.
International orthopaedics4 min read
In radioiodine-refractory differentiated thyroid cancer, Pentixafor and FDG PET/CT detected similar proportions of lesions, but FDG had higher median uptake measures overall.
Molecular imaging and biology3 min read
A 48-patient retrospective study found that PET-derived heterogeneity, metabolic tumor volume and total lesion glycolysis were associated with Ryan 3 poor pathological response after chemoradiotherapy, though the findings do not establish causation.
Annals of nuclear medicine4 min read
In a 714-patient analysis, small tumors did not show higher complete-response rates, while larger tumors were linked to more residual disease.
Annals of surgical oncology3 min read
Most practitioners considered quality-of-life assessment important for treatment planning and informed decisions, yet only two of 10 described regular use of formal tools.
Laryngoscope investigative otolaryngology4 min read
A SINEUP-based RNA tool was associated with a more hepatocyte-like gene, protein and metabolic profile in Huh7-based three-dimensional microtissues. The study also found higher reported CYP activity and mixed responses to drug exposures, while the authors said the model still needs further validation.
Journal of liver cancer4 min read
The study reports a candidate plasma marker that distinguished colorectal cancer from comparison groups internally and a laboratory model connecting the RNA to altered mitochondrial translation and succinate.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)5 min read
Researchers used onion-peel extract to make O3, a zinc oxide preparation tested on human A549 lung adenocarcinoma cells. The cells showed lower viability and associated changes in morphology, cell-cycle distribution, ROS and p53 localization, but the findings do not establish clinical efficacy or safety.
Frontiers in chemistry4 min read