Review Reports a Hidden Cost of Function in Protein Evolution
A review of experimental and computational evidence describes a measurable gap between folding stability and the demands of biological function.
Scientific publication4 min read
Research field
Biology & Life Sciences
Cells, genes, microbes, organisms, ecosystems, and evolution.
12 published articles4 subjects
Latest in Biology
Many cryo-EM runs outperform one-shot reconstruction on mixtures
A new arXiv preprint reports a reconstruction ensemble that combined multiple cryo-EM ab initio jobs. It achieved 97.4% accuracy on a 45-class asymmetric synthetic benchmark, versus 34.6% for the best single-shot run, and separated four major ribosomal assembly states from junk in an unfiltered experimental stack.
Scientific publication3 min read
Small Subtrees Can Rebuild Two Evolutionary Trees, But Not Always
A mathematical analysis of pooled subtree information finds a sharp contrast: three-leaf buckets can hide distinct labelled tree pairs, while n-1 buckets recover pairs across broad size ranges, with small exceptions.
Scientific publication4 min read
Proofreading model links accuracy to the driven layer
A mathematical analysis of a kinetic-proofreading network finds that modeled error varies with downstream cycle structure and drive strength.
Scientific publication4 min read
Bee-Like Simulations Find Narrow Route to Gravity-Based Signals
A computer model of evolving bee-like colonies found that direct pointing was limited to a moderate food landscape, while stable transitions to gravity-referenced signaling were found in some simulated runs.
Scientific publication4 min read
Preprint maps how genome length relates to species splitting
This preprint derives a critical genome-length formula for fragmentation in a mating-threshold population, with scaling laws that change as population size, mutation rate and transient genealogical width vary.
Scientific publication5 min read
Gaucher disease models suggest red cells may struggle in tight spaces
A new preprint combines blood-cell measurements with computer simulations to examine how Gaucher disease-associated red-cell changes relate to deformation, confined flow and viscosity.
Scientific publication6 min read
Evolutionary model links reliable expression to slower adaptation
An abstract genotype–phenotype model associated higher penetrance with mutational robustness and lower access to alternative high-fitness regions, while simulations linked infrequent environmental change with penetrance and frequent change with adaptability.
Scientific publication4 min read
Australian Soil-Water Model Performs Better in Western Regions
The SWEB model estimated crop water use and root-zone soil moisture across Australian grain regions, with correlations of 0.70 to 0.85 across most regions and higher errors in southeast Australia.
GRDC Grains Research Update 2026, Goondiwindi, Australia, 3-4 March, 149-1573 min read
Preprint: A mechanical model connects tissue growth that stops, continues or stays in proportion
A new arXiv preprint proposes one continuum-mechanics framework for bounded, unbounded and proportionate tissue growth. Its central results are theoretical: the model predicts a stress threshold, long-term proportions set by material parameters and a turnover-dependent growth rate, but it does not test those predictions against biological measurements.
Scientific publication6 min read
Preprint finds ecological instability need not bring near-perfect species correlations
A modeling preprint suggests that near-perfect correlations between species are not a universal sign of ecological instability; the signal depends on whether a slowly relaxing mode is visible above background fluctuations.
Scientific publication3 min read
Preprint models how uneven selection can reshape trait evolution
A new arXiv preprint develops models in which reproduction and survival favor different trait values and their selection strengths vary across space or time. The analysis predicts shifted optima, asymmetric or potentially two-peaked effective fitness landscapes, and wider or displaced distributions of simulated trait outcomes.
Scientific publication6 min read