Subject
Cell processes, proteins, signaling, gene expression, and molecular mechanisms.
A phase-resolved study of cultured mouse stem cells found that compartment strength rose abruptly at the start of S phase, with stronger A-A contacts and a more consolidated strong-A signal.
eLife4 min read
A 24-hour study in differentiated SH-SY5Y cells found DHA had the strongest PSD-95 and glutamatergic protein responses, while EPA and mixed compositions showed weaker or distinct profiles.
Frontiers in synaptic neuroscience4 min read
Researchers used broad serum screening and a separate targeted assay to explore whether serotonin could help identify calcific aortic valve stenosis.
Frontiers in pharmacology3 min read
A rat study reports weight gain alongside molecular changes in the dorsal raphe nucleus after long-term olanzapine exposure.
Frontiers in pharmacology4 min read
A single-center retrospective cohort found that non-cryopreserved grafts were linked with similar engraftment and overall survival to cryopreserved grafts. Hospital stays were shorter, but mucositis was more frequent, and the non-randomized design limits causal conclusions.
Frontiers in oncology4 min read
Three rosemary monoterpenes affected the human serotonin transporter in engineered cells, but the partial, high-concentration effect does not establish antidepressant activity.
Frontiers in pharmacology4 min read
A study of petal cells found more epidermis-enriched genes, layer-exclusive expression changes and PhDEF binding sites in the epidermis than in the mesophyll. The results suggest that cell-layer context may shape how PhDEF operates, but they do not prove that every bound gene is regulated by PhDEF.
eLife4 min read
A single infusion of edited blood-forming stem cells was associated with donor-cell engraftment and better movement, cerebellar, heart and pancreatic measures in humanized Friedreich’s ataxia mice. The findings were incomplete and remain preclinical, with some abnormalities persisting and the proposed editing threshold not prospectively validated.
The Journal of clinical investigation4 min read
A large CMOS capacitance sensor tracked label-free movement from individual cells to cancer-cell spheroids and millimetre-scale engineered tissues, while offering a much wider field than the optical comparison.
Lab on a chip4 min read
A paper asks what accounts for ion-mobility differences between GRGDS and SDGRG, but the supplied sectioned text contains no methods, sample details or study results.
The Analyst3 min read
MARLOWE ranked microbial contributors well in controlled tests, but its results were less reliable for secondary sources and less specific than MiCId in the broader comparison.
Scientific reports4 min read
A systematic review of GLP-1 and dual GIP/GLP-1 drugs found no consistent signal of psychiatric harm, but said the evidence is too mixed to determine whether most reported outcomes are treatment-related.
Current psychiatry reports4 min read
In cultured U2OS cells, repeated sodium arsenite exposure was linked to smaller stress granules, reduced assembly at lower follow-up doses and less docking with P-bodies.
Journal of cell science4 min read
A laboratory study used temperature-responsive material patterns to turn planar hydrogel constructs into programmed 3D forms, then measured curvature, motion, viability and cell behavior during culture.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)5 min read
Digital FDG PET/CT detected more cases of cranial giant cell arteritis than an initial scan reading and had 100% specificity in the analyzed group, while the study stopped short of showing it should replace ultrasound or biopsy.
European journal of nuclear medicine and molecular imaging4 min read