Review Reports a Hidden Cost of Function in Protein Evolution
A review of experimental and computational evidence describes a measurable gap between folding stability and the demands of biological function.
Scientific publication4 min read
Subject
Cells & Molecular Biology
Cell processes, proteins, signaling, gene expression, and molecular mechanisms.
6 published articles6 specialties
Latest in Cells & Molecules
Many cryo-EM runs outperform one-shot reconstruction on mixtures
A new arXiv preprint reports a reconstruction ensemble that combined multiple cryo-EM ab initio jobs. It achieved 97.4% accuracy on a 45-class asymmetric synthetic benchmark, versus 34.6% for the best single-shot run, and separated four major ribosomal assembly states from junk in an unfiltered experimental stack.
Scientific publication3 min read
Proofreading model links accuracy to the driven layer
A mathematical analysis of a kinetic-proofreading network finds that modeled error varies with downstream cycle structure and drive strength.
Scientific publication4 min read
Gaucher disease models suggest red cells may struggle in tight spaces
A new preprint combines blood-cell measurements with computer simulations to examine how Gaucher disease-associated red-cell changes relate to deformation, confined flow and viscosity.
Scientific publication6 min read
Australian Soil-Water Model Performs Better in Western Regions
The SWEB model estimated crop water use and root-zone soil moisture across Australian grain regions, with correlations of 0.70 to 0.85 across most regions and higher errors in southeast Australia.
GRDC Grains Research Update 2026, Goondiwindi, Australia, 3-4 March, 149-1573 min read
Preprint: A mechanical model connects tissue growth that stops, continues or stays in proportion
A new arXiv preprint proposes one continuum-mechanics framework for bounded, unbounded and proportionate tissue growth. Its central results are theoretical: the model predicts a stress threshold, long-term proportions set by material parameters and a turnover-dependent growth rate, but it does not test those predictions against biological measurements.
Scientific publication6 min read